|
Thomas M. Laue
Professor of Biochemistry and Molecular Biology Director, Biomolecular Interaction Technologies Center (BITC) Director, Center to Advance Molecular Interaction Science (CAMIS) University of New Hampshire Rudman Hall 379 Durham, New Hampshire 03824 Tel. (603) 862-2459 Fax: (603) 862-0031 E-mail: Tom.Laue@unh.edu |
||
| RESEARCH INTERESTS The research in my laboratory, the Center to Advance Molecular Interaction Science (CAMIS), is directed toward the development of direct physical methods for determining properties of macromolecules, including mass, charge, size, shape, and solubility, as well as the state of aggregation and the extent of ligand binding. Along with standard optical methods (absorbance, fluorescence, circular dichroism), our lab has developed novel instrumentation for sedimentation analysis (both equilibrium and velocity) and charge analysis (steady state electrophoresis). These methods are being applied to a wide range of macromolecular interactions of importance, including those in blood coagulation, DNA transcriptional regulation, viral DNA integration, and gel formation. Moreover, we are now studying the contribution of macromolecular charge to structure, stability, and assembly through a unique combination of physical methods. |
||
| INDUSTRY/UNIVERSITY
COOPERATIVE RESEARCH CENTER The Biomolecular Interaction Technologies Center (BITC) is a National Science Foundation-sponsored consortium of academic institutions and industrial partners. BITC member companies underwrite research projects and the development of resources in cutting-edge technologies, particularly those of interest in the development of safe and effective drugs. Member companies include pharmaceutical firms and instrument manufacturers. BITC holds annual workshops at UNH on methods and technologies essential to the study of biomolecular interactions, and opens the workshop lectures to UNH scientists and students. |
||
| EDUCATION Ph.D. University of Connecticut. Area: Biophysics and Biochemistry, 1981 B.A. The Johns Hopkins University. Area: Natural Sciences, 1971 |
||
| PROFESSIONAL
POSITIONS Director, Biomolecular Interaction Technologies Center, 2000 Director, Center to Advance Molecular Interaction Science, 1999 Professor, Biochemistry and Molecular Biology, U. New Hampshire, 1995 Associate Professor, Biochemistry and Molecular Biology, U. New Hampshire, 1989 Assistant Professor, Biochemistry and Molecular Biology, U. New Hampshire, 1989 Research Associate, Chemistry, U. Oklahoma, 1981 |
||
AWARDS AND
PROFESSIONAL ACTIVITIES |
||
| HONORS University of New Hampshire Outstanding Associate Professor, 1994 Genentech Research Prize, 1995 |
||
|
SELECTED PUBLICATIONS |
||
| PATENTS Laue, T.M., Yphantis, D.A., and Hazard, A.L. "Apparatus and Method for Macromolecular Charge Determination" Pat. No. 4,994,161, granted 19 February 1991. |
||
| TECHNICAL REPORTS Laue, T.M. "Optical Systems of the XLA Ultracentrifuge" (1996) Applications Data Note for Spinco Division of Beckman Instruments, Inc. P.O.Box 10200, Palo Alto, California. Laue, T.M. (1992) “Short Column Sedimentation Equilibrium Analysis for Rapid Characterization of Macromolecules in Solution.” Palo Alto, CA:Beckman Instruments, Inc., Technical Information DS835. Laue, T.M., Schuster, T.M., Yphantis, D.A., Lewis, M.L. and Van Holde, K.H. (1986) "The Future of Analytical Ultracentrifugation" National Science Foundation, Biological Instrumentation Program report, 18 pp. Green, R.H., Godfrey, J.F., Laue, E.G., Laue, T.M., Paik, W.W., and Wardle, M.D. (1972) "Quartz Crystal Microbalance Used in Biological Studies" NASA Tech Brief No. B72-10243. |
||
| COMPUTER PROGRAMS Laue, T.M. (in preparation) “Chaos: Multi-component interaction simulator using chaos theory” C++ for Windows. Laue, T.M. (in preparation) “XLIFdb: File database management for the XLI Analytical Ultracentrifuge” C++ and Access, written for Windows NT. Laue, T.M. (in preparation) “XLI32 Operating System for the XLA Analytical Ultracentrifuge Version 1.x” 74000 lines of C++ code, written for Windows NT, multithreaded, OLE2 compatible container/sever, includes fluorescence/luminescence detection. Laue, T.M. and Moody, T.P. (1995) “SseSim: Finite Difference Simulation of Broad-zone Analytical Electrophoresis” 21000 lines of C++ code, written for Windows 3.x, Windows 95 and a generic version (in C) for other C compilers. Hayes, D.B., Philo, J.P. and Laue, T.M. (1994) “SedNTerp: Interpretation of Sedimentation Data Version 1.x” 2000 lines of Visual Basic code, written for Windows 3.x. Laue, T.M. (1993) "XLA2000+ Operating System for the XLA Analytical Ultracentrifuge Version 2.x" 58000 lines of C++ code, written for Windows 3.1. (Commercialized version used by Beckman Instruments). Laue, T.M. (1993) "XLA2000+ Operating System for the XLA Analytical Ultracentrifuge Version 1.x" 26000 lines of C++ code, written for Windows 3.1 (Prototype Version used only in lab) |
||